Effect of Maternal and Paternal Nutrition on DNA Methylation in the Offspring: A Systematic Review of Human and Animal Studies
ثبت نشده
چکیده
Maternal or paternal diet may influence health throughout the life course. This is a systematic review of studies in humans and animals specifically investigating DNA methylation in progeny in relation to diet of the mother or father, or previous generations. There is an overview of the types of diet studied and the metabolic paths affected. Food deprivation in humans and animal models, studies on imprinted genes, hypothalamic pituitary adrenal axis and influence of paternal diet are discussed.
منابع مشابه
Dietary Proteins, Developmental Programming, and Potential Implication in Maternal Obesity
Background: Proteins are known mainly based on their metabolic and nutritional functions including protein synthesis and a source of energy. In spite of various physiological properties attributed to proteins, their functions have neither been addressed by assessing quality of proteins nor by nutrition and dietetic practices. Methods: Studies were included if they were randomized animal studies...
متن کاملThe role and importance of DNA methylation in spermatogenesis process
Background: DNA methylation is one of the epigenetic marks that are created by de novo DNA methylation and be maintained through cell division. This process is catalyzed by DNA methyltransferases. DNA methylation establishment in germ line is important, since they have the potential to regulate gene expression in offspring and improper DNA methylation patterns in germ lines has serious conseque...
متن کاملP-19: The Effect of Mice Maternal Diet Supplemented with Omega-3 Fatty Acids on The Testicular Structure of Offspring: Stereological Study
Background Despite the bulk of studies on fatty acid supplementation in maternal diet and confirmed the positive effects on brain and vision, these effects on offspring reproductive organs have not been tested. The aim of the present study was to stereological evaluate the effect of feeding Fish Oil (FO) for mothers on the testis structure of offspring. MaterialsAndMethods Sixty mature female N...
متن کاملO-11: N-a-acetyltransferase 10 Protein Regulates DNA Methylation and Embryonic Development
Background Genomic imprinting is a heritable and developmentally essential phenomenon by which gene expression occurs in an allele-specific manner1. While the imprinted alleles are primarily silenced by DNA methylation, it remains largely unknown how methylation is targeted to imprinting control region (ICR), also called differentially methylated region (DMR), and maintained. Here we show that ...
متن کاملUpdate on riboflavin and multiple sclerosis: a systematic review
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Riboflavin plays an important role in myelin formation, and its deficiency is implicated as a risk factor for multiple sclerosis. Here, we systematically reviewed the literature concerning the health benefits of riboflavin on MS. The literature recorded within four main databases, including rel...
متن کامل